Professional

BioMin a new generation toothpaste
  • Up to 6X longer therapeutic availability
  • Faster remineralisation
  • Acid neutralisation
  • Internal tubule occlusion
  • 530 ppm
Developed at Queen Mary University, London: 10 years in development 7 PhDs
BioMinF is a breakthrough innovation that could significantly reduce dental decay.

Prof. Hill

“I started trialling BioMin on my patients for approximately 6 months now and the feedback that I’m getting is fantastic”

Dr Ellie .P Bondi Junction

How does BioMin F work?
BioMin F responds to acidity

BioMin is a bioglass that adheres to the tooth’s surface, slowly dissolving in saliva over a period of 8 to 12 hours. BioMin F releases calcium Ca2+, phosphate PO43- and fluoride  F- ions which raise pH and promote the formation of fluorapatite.  When faced with an acid challenge the bioglass responds by dissolving and raising the pH to minimise the acid dissolution of the enamels apatite crystals.

Essentially BioMinF is designed to help re-establish lost apatite.

Retards demineralisation

BioMinF includes a slow-release fluoride which helps retard the demineralisation process to further protect the tooth from decay.

Traditional toothpaste rapidly loses fluoride

Y Axis : Remin rate : Mass Gain (gcm-2 Hr-1 X10-5)

Available fluoride post brushing with 1450 ppm and 5,000 ppm fluoridated toothpaste. Gillam D, Dentine Hypersensitivity: Advances in Diagnosis, Management, and Treatment 2015. p.169-170. 

After brushing with a fluoride dentifrice, fluoride levels in saliva and biofilms decrease sharply.  Over a period of 15 min to 2 hr fluoride concentration typically drops to 1– 3 ppm, and continues to decline to 0.5 to 0.02 ppm quite rapidly.P1

BioMin F up to 12 hours

Fluoride-containing bio-active glass dissolves slowly helping maintain therapeutic levels.

BioMin F : Therapeutic fluoride available up to 12 hours
5,000 ppm fluoridated toothpaste
1,450 ppm fluoridated toothpaste

Adapted from Gillam et al, Dentine Hypersensitivity: Advances in Diagnosis, Managment and Treatment. On file: BioMin Technical file: Queen Mary Universtiy of London.

A constant supply of low levels of fluoride in biofilm/saliva/dental interface is considered beneficial in preventing dental caries p2.

BioMinF’s slow release formula continues to supply fluoride for up to 12 hours to elevate fluoride levels in the oral cavity.

Higher remineralisation rate
BioMin has a higher remineralisation/repair rate

Increasing the phosphate content of BioGlasses significantly drives the remineralisation rate. BioMin has close to 3X the phosphate content.

 BioMin retards demineralisation with active acid resistance

BioMin’s controlled release responds to acids, as BioMin dissolves OH ions are released helping to neutralise acids, lift pH and drive remineralisation over demineralisation.

Fixing white spots may be as easy as changing your toothpaste to BioMin

BioMin F has been clinically shown# to assist with the repair of demineralised white spots / white marks on teeth.BioMin C has a similar repair mechanism.

BioMin F superior remineralising vs 9,000 ppm fluoride gel, faster and deeper.
  • Remin rate

Mineral gain (ΔZ, vol, µm)

Adapted from: Bakry AS, et al, A Novel Fluoride Containing Bioactive Glass Paste is Capable of Re-Mineralizing Early Caries Lesions. Materials. 2018; 11(9):1636.

“BioMin F paste can be considered an effective remineralizing agent for white spot Lesions”

(A. Control B. 9,000 ppm fluoride 4 min, C. 9,000 ppm fluoride 24 hr, D. BioMin F)

Sub-surface remineralisation

The low fluoride content of the BioMin F (vs. 9,000 ppm fluoride gel), allowed the penetration of BioMin F rich content of calcium and phosphate through the porous enamel sub-surface, causing the re-mineralization of the demineralized enamel lesion rather than remineralizing the outer enamel surface

Internally occludes: 90% reduction

Many regular toothpaste occlude tubules by laying a coating over the open tubules surface.

BioMin is able to internally and externally occlude the open tubules, with up to 50% of particles small enough to enter the open tubule, preferentially forming fluorapatite (BioMin F) or hydroxyapatite (BioMin C) on the internal tubular walls.

BioMin F exhibits a high-level reduction in hydraulic conductance, with up to 90% reduction, significantly more than tested market-leading brands.

Date on file: QMU London

Family strength, low fluoride toothpaste  (530 ppm)  with reduced risk of fluorosis
BioMin F 530 ppm
18 months to 5 yrs 500 - 550 ppm
Ages 6 to adult from 1,000 ppm
Ages 6 to adult from 1,500 ppm

BioMin F vs ADA fluoride recommendation

With less fluoride being washed away, BioMinF is able to have relatively lower fluoride levels of 530 ppm (when packed), 60% less than conventional fluoride toothpaste. Generally recommended for ages 6 to 106 or as prescribed by a dental professional.

BioMin F

Glycerin, Silica, PEG 400, Fluoro CalciumPhosphoSilicate, Sodium Lauryl Sulphate, Titanium Dioxide, Aroma, Carbomer,  Potassium Acesulfame.


BioMin C

Glycerin, Silica, PEG, ChloroCalciumPhosphoSilicate, Sodium Lauryl Sulphate, Titanium Dioxide, Flavouring, Carbopol, Potassium Acesulfame.

BioMin F delivers significantly superior tubule occlusion

  • Comparative Evaluation of Desensitizing Dentifrices containing BioMin®, Novamin® and Fluoride on Dentinal Tubule Occlusion before and after a Citric Acid Challenge  – Article

Phosphates drive remineralisation rate, reduce time to commence remineralisation and pH levels required

  • Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid Article
  • High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses Article

Above 45 ppm calcium fluorite forms

  • Fluoride drives remineralisation, high levels of fluoride create insoluble calcium fluorite Article

Remineralisation

  • BioMin can Remineralise White Spot Lesions Surrounding Orthodontic Brackets Article
  • BioMin effectively remineralises white spot lesions, comparison vs 9,000 ppm fluoride gel, remineralises subsurface Article
  • Optimal remineralization depends on exposure to low concentrations of calcium, phosphate and fluoride for prolonged periods Article
+ How ?
How does BioMin F work?
BioMin F responds to acidity

BioMin is a bioglass that adheres to the tooth’s surface, slowly dissolving in saliva over a period of 8 to 12 hours. BioMin F releases calcium Ca2+, phosphate PO43- and fluoride  F- ions which raise pH and promote the formation of fluorapatite.  When faced with an acid challenge the bioglass responds by dissolving and raising the pH to minimise the acid dissolution of the enamels apatite crystals.

Essentially BioMinF is designed to help re-establish lost apatite.

Retards demineralisation

BioMinF includes a slow-release fluoride which helps retard the demineralisation process to further protect the tooth from decay.

+ 6X longer fluoride
Traditional toothpaste rapidly loses fluoride

Y Axis : Remin rate : Mass Gain (gcm-2 Hr-1 X10-5)

Available fluoride post brushing with 1450 ppm and 5,000 ppm fluoridated toothpaste. Gillam D, Dentine Hypersensitivity: Advances in Diagnosis, Management, and Treatment 2015. p.169-170. 

After brushing with a fluoride dentifrice, fluoride levels in saliva and biofilms decrease sharply.  Over a period of 15 min to 2 hr fluoride concentration typically drops to 1– 3 ppm, and continues to decline to 0.5 to 0.02 ppm quite rapidly.P1

BioMin F up to 12 hours

Fluoride-containing bio-active glass dissolves slowly helping maintain therapeutic levels.

BioMin F : Therapeutic fluoride available up to 12 hours
5,000 ppm fluoridated toothpaste
1,450 ppm fluoridated toothpaste

Adapted from Gillam et al, Dentine Hypersensitivity: Advances in Diagnosis, Managment and Treatment. On file: BioMin Technical file: Queen Mary Universtiy of London.

A constant supply of low levels of fluoride in biofilm/saliva/dental interface is considered beneficial in preventing dental caries p2.

BioMinF’s slow release formula continues to supply fluoride for up to 12 hours to elevate fluoride levels in the oral cavity.

+ Remineralisation
Higher remineralisation rate
BioMin has a higher remineralisation/repair rate

Increasing the phosphate content of BioGlasses significantly drives the remineralisation rate. BioMin has close to 3X the phosphate content.

 BioMin retards demineralisation with active acid resistance

BioMin’s controlled release responds to acids, as BioMin dissolves OH ions are released helping to neutralise acids, lift pH and drive remineralisation over demineralisation.

Fixing white spots may be as easy as changing your toothpaste to BioMin

BioMin F has been clinically shown# to assist with the repair of demineralised white spots / white marks on teeth.BioMin C has a similar repair mechanism.

+ BioMin vs 9,000 ppm fluoride
BioMin F superior remineralising vs 9,000 ppm fluoride gel, faster and deeper.
  • Remin rate

Mineral gain (ΔZ, vol, µm)

Adapted from: Bakry AS, et al, A Novel Fluoride Containing Bioactive Glass Paste is Capable of Re-Mineralizing Early Caries Lesions. Materials. 2018; 11(9):1636.

“BioMin F paste can be considered an effective remineralizing agent for white spot Lesions”

(A. Control B. 9,000 ppm fluoride 4 min, C. 9,000 ppm fluoride 24 hr, D. BioMin F)

Sub-surface remineralisation

The low fluoride content of the BioMin F (vs. 9,000 ppm fluoride gel), allowed the penetration of BioMin F rich content of calcium and phosphate through the porous enamel sub-surface, causing the re-mineralization of the demineralized enamel lesion rather than remineralizing the outer enamel surface

+ Tubule occlusion
Internally occludes: 90% reduction

Many regular toothpaste occlude tubules by laying a coating over the open tubules surface.

BioMin is able to internally and externally occlude the open tubules, with up to 50% of particles small enough to enter the open tubule, preferentially forming fluorapatite (BioMin F) or hydroxyapatite (BioMin C) on the internal tubular walls.

BioMin F exhibits a high-level reduction in hydraulic conductance, with up to 90% reduction, significantly more than tested market-leading brands.

Date on file: QMU London

+ Content
Family strength, low fluoride toothpaste  (530 ppm)  with reduced risk of fluorosis
BioMin F 530 ppm
18 months to 5 yrs 500 - 550 ppm
Ages 6 to adult from 1,000 ppm
Ages 6 to adult from 1,500 ppm

BioMin F vs ADA fluoride recommendation

With less fluoride being washed away, BioMinF is able to have relatively lower fluoride levels of 530 ppm (when packed), 60% less than conventional fluoride toothpaste. Generally recommended for ages 6 to 106 or as prescribed by a dental professional.

BioMin F

Glycerin, Silica, PEG 400, Fluoro CalciumPhosphoSilicate, Sodium Lauryl Sulphate, Titanium Dioxide, Aroma, Carbomer,  Potassium Acesulfame.


BioMin C

Glycerin, Silica, PEG, ChloroCalciumPhosphoSilicate, Sodium Lauryl Sulphate, Titanium Dioxide, Flavouring, Carbopol, Potassium Acesulfame.

+ Clinical

BioMin F delivers significantly superior tubule occlusion

  • Comparative Evaluation of Desensitizing Dentifrices containing BioMin®, Novamin® and Fluoride on Dentinal Tubule Occlusion before and after a Citric Acid Challenge  – Article

Phosphates drive remineralisation rate, reduce time to commence remineralisation and pH levels required

  • Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid Article
  • High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses Article

Above 45 ppm calcium fluorite forms

  • Fluoride drives remineralisation, high levels of fluoride create insoluble calcium fluorite Article

Remineralisation

  • BioMin can Remineralise White Spot Lesions Surrounding Orthodontic Brackets Article
  • BioMin effectively remineralises white spot lesions, comparison vs 9,000 ppm fluoride gel, remineralises subsurface Article
  • Optimal remineralization depends on exposure to low concentrations of calcium, phosphate and fluoride for prolonged periods Article
How does BioMin F work?
BioMin F responds to acidity

BioMin is a bioglass that adheres to the tooth’s surface, slowly dissolving in saliva over a period of 8 to 12 hours. BioMin F releases calcium Ca2+, phosphate PO43- and fluoride  F- ions which raise pH and promote the formation of fluorapatite.  When faced with an acid challenge the bioglass responds by dissolving and raising the pH to minimise the acid dissolution of the enamels apatite crystals.

Essentially BioMinF is designed to help re-establish lost apatite.

Retards demineralisation

BioMinF includes a slow-release fluoride which helps retard the demineralisation process to further protect the tooth from decay.

Traditional toothpaste rapidly loses fluoride

Available fluoride post brushing with 1450 ppm and 5,000 ppm fluoridated toothpaste. Gillam D, Dentine Hypersensitivity: Advances in Diagnosis, Management, and Treatment 2015. p.169-170. 

After rinsing or brushing with a fluoride dentifrice, fluoride levels in saliva and biofilms decrease sharply.  Over a period of 15 min to 2 hours the fluoride concentration in the oral cavity typically drops to 1– 3 ppm, and continues to decline to 0.5 to 0.02 ppm quite rapidly.P1

Fluoride-containing bio-active glass dissolves slowly helping maintain therapeutic levels.

BioMin F up to 12 hours
BioMin F : Therapeutic fluoride available up to 12 hours
5,000 ppm fluoridated toothpaste
1,450 ppm fluoridated toothpaste

Adapted from Gillam et al, Dentine Hypersensitivity: Advances in Diagnosis, Managment and Treatment. On file: BioMin Technical file: Queen Mary Universtiy of London.

A constant supply of low levels of fluoride in biofilm/saliva/dental interface is considered beneficial in preventing dental caries p2.

BioMinF’s slow release formula continues to supply fluoride for up to 12 hours to elevate fluoride levels in the oral cavity.

BioMin has a higher remineralisation/repair rate

Increasing the phosphate content of BioGlasses significantly drives the remineralisation rate. BioMin has close to 3X the phosphate content.

 BioMin retards demineralisation with active acid resistance

BioMin’s controlled release responds to acids, as BioMin dissolves OH ions are released helping to neutralise acids, lift pH and drive remineralisation over demineralisation.

Fixing white spots may be as easy as changing your toothpaste to BioMin

BioMin F has been clinically shown# to assist with the repair of demineralised white spots / white marks on teeth.BioMin C has a similar repair mechanism.

BioMin F superior remineralising vs 9,000 ppm fluoride gel, faster and deeper.
  • Remin rate

Mineral gain (ΔZ, vol, µm)

Adapted from: #Bakry AS, et al, A Novel Fluoride Containing Bioactive Glass Paste is Capable of Re-Mineralizing Early Caries Lesions. Materials. 2018; 11(9):1636.

“BioMin F paste can be considered an effective remineralizing agent for white spot Lesions”#

(A. Control B. 9,000 ppm fluoride 4 min, C. 9,000 ppm fluoride 24 hr, D. BioMin F)

Sub-surface remineralisation

The low fluoride content of the BioMin F (vs. 9,000 ppm fluoride gel), allowed the penetration of BioMin F rich content of calcium and phosphate through the porous enamel sub-surface, causing the re-mineralization of the demineralized enamel lesion rather than remineralizing the outer enamel surface

Internally occludes: 90% reduction

Many regular toothpaste occlude tubules by laying a coating over the open tubules surface.

BioMin is able to internally and externally occlude the open tubules, with up to 50% of particles small enough to enter the open tubule, preferentially forming fluorapatite (BioMin F) or hydroxyapatite (BioMin C) on the internal tubular walls.

BioMin F exhibits a high-level reduction in hydraulic conductance, with up to 90% reduction, significantly more than tested market-leading brands.

Date on file: QMU London

Family strength, low fluoride toothpaste  (530 ppm)  with reduced risk of fluorosis
BioMin F 530 ppm
18 months to 5 yrs 500 - 550 ppm
Ages 6 to adult from 1,000 ppm
Ages 6 to adult from 1,500 ppm

BioMin F vs ADA fluoride recommendation

With less fluoride being washed away, BioMinF is able to have relatively lower fluoride levels of 530 ppm (when packed), 60% less than conventional fluoride toothpaste. Generally recommended for ages 6 to 106 or as prescribed by a dental professional.

BioMin F

Glycerin, Silica, PEG 400, Fluoro CalciumPhosphoSilicate, Sodium Lauryl Sulphate, Titanium Dioxide, Aroma, Carbomer,  Potassium Acesulfame.

BioMin C

Glycerin, Silica, PEG, ChloroCalciumPhosphoSilicate, Sodium Lauryl Sulphate, Titanium Dioxide, Flavouring, Carbopol, Potassium Acesulfame.

BioMin F delivers significantly superior tubule occlusion

  • Comparative Evaluation of Desensitizing Dentifrices containing BioMin®, Novamin® and Fluoride on Dentinal Tubule Occlusion before and after a Citric Acid Challenge  – Article

Phosphates drive remineralisation rate, reduce time to commence remineralisation and pH levels required

  • Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid Article
  • High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses Article

Above 45 ppm calcium fluorite forms

  • Fluoride drives remineralisation, high levels of fluoride create insoluble calcium fluorite Article

Remineralisation

  • BioMin can Remineralise White Spot Lesions Surrounding Orthodontic Brackets Article
  • BioMin effectively remineralises white spot lesions, comparison vs 9,000 ppm fluoride gel, remineralises subsurface Article
  • Optimal remineralization depends on exposure to low concentrations of calcium, phosphate and fluoride for prolonged periods Article
The BioMin development team
null

Professor Robert Hill

Director and Chief Scientific Officer

Biography

Professor Robert Hill, Director and Chief Scientific Officer, currently holds the Chair of Physical Sciences in the Dental Institute at Queen Mary University, London.

Formerly Professor of Biomaterials at Imperial College. He is an expert on bioactive glass and apatite chemistry. He was part of the Materials Group at LGC that won the Queens Award for Technological Achievement in 1984.

Papers: 250 +

Patents: 20 +

null

Dr David Gillam

Clinical Consultant & Non-executive Director

Biography

Also Senior Clinical Lecturer in Periodontology at Barts London School of Medicine and Dentistry (QMDI).

He has considerable expertise concerning Dentine Hypersensitivity and Periodontal Disease. He has broad industry experience with leading oral health companies.

He published over 50 papers and one of the first papers on the occlusion of dentine tubules using bioactive glass. In 2015 he was the editor of the book “Dentine Hypersensitivity”.

null

Professor Delia Brauer

Contributing Researcher

Biography

Professor at Otto Schott Institute of Materials Research, University of Jena, Germany.

Jena is one of the leading centres for Glass Research in the World and Professor Brauer developed Fluorine containing bioglasses.

In 2015 Professor Brauer was awarded the Gottardi Prize of the International Commission of Glass.

null

Dr Natalia Karpukhina

Contributing Researcher

Biography

Contributing Researcher, is a Lecturer in Dental Physical Sciences and is a Solid State NMR Spectrocopist at Queen Mary University, London and has used 31P and 19F NMR to follow Demineralisation and Remineralisation processes.

Author of more than 70 publications including a major scientific review of Halide Glasses and a paper on “Fluoride-containing bioactive glasses: effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid.”

null

Dr Andy Bushby

Contributing Researcher

Biography

Dr Bushby’s Reader in Materials Director of SEMS -NPU Collaboration, Queen Mary, London.
Dr Bushby’s research is centred on the micro- and nano-mechanics of materials and structures. He is a leading expert in the technique of nanoindentation for small-scale mechanical property measurement and contributes to ISO Standards working groups for instrumented indentation.

null

Dr Xiaojing Chen

Contributing Researcher

Biography

Contributing Researcher, holds a CSIC scholarship given to the top 1% of Chinese Students. Her Ph.D. is on Chloride Containing Bioactive Glasses.

Dr Chen is a co-inventor of BioMin’s Chloride Bioactive Glass Patent, and was awarded the 2014 Margaret K B Day Scholarship Prize for Female PhD. students studying in Britain.

References


P1 ten Cate J M,  Contemporary perspective on the use of fluoride products in caries prevention.  British Dental Journal 214, 161 – 167

p2  Rošin-Grget, K; Peroš, K; Sutej, I; Bašić, K (Nov 2013). “The cariostatic mechanisms of fluoride.”. Acta medica academica 42 (2): 179–88. doi:10.5644/ama2006-124 (2013)