BioMin Clinical papers – Remineralisation

Biomin F^® toothpaste demonstrated more fluoride content and greater potential to promote remineralization of demineralized human enamel compared to Novamin^®.  BiominF toothpaste presented higher micro-hardness values on remineralization. BioMin F packaged fluoride content is 530 ppm vs NovaMin containing toothpaste at 1,450ppm.

Biomin paste has a high capacity to remineralize white spot lesions associated with orthodontic brackets when compared to fluoride application.

The low fluoride content of the BioMin F (vs. 9,000 ppm fluoride gel), allowed the penetration of BioMin F rich content of calcium and phosphate through the porous enamel sub-surface, causing the re-mineralization of the demineralized enamel lesion rather than remineralizing the outer enamel surface.

The BioMin F-based toothpaste showed better remineralizing capability than did the NovaMin based toothpaste, according to micro-CT and surface roughness evaluations, especially after 5 min. This finding could be attributed to a difference in composition; the NovaMin toothpaste is based on a conventional 45S5 (Bioglass) composition, which contains no fluoride, whereas the BioMin F

A head to head comparison of BioMin F vs 1450 ppm Colgate monofluorophosphate toothpaste. BioMin showed a significantly greater remineralisation rate (Δ 118.73  vs Δ 60.54) measured using mean Vickers Hardness Number.

BioMin F in comparison to Colgate 1450 ppm fluoride toothpaste, delivers a greater surface micro hardness, a smoother enamel surface and greater enamel volume restoration (remineralisation) .

Fluoride-containing bioactive glasses: Effect of glass design and structure on degradation, pH and apatite formation in simulated body fluid

Fluoride in glass forms fluorapatite, increasing phosphate favours apatite formation.

The ability of bioactive glasses to form apatite in body fluids is also used in toothpaste for treating dentine hypersensitivity.

High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses

An increase in phosphate or fluoride content allowed for apatite formation at lower pH.

High phosphate content fluoride-containing glasses are particularly suited for use in remineralizing dentifrices.

It would still be desirable to reduce the enamel abrasivity of 45S5 bioglass, since the outermost enamel layer that becomes fluoridated with use of a fluoride toothpaste is very thin and removal of this protective layer by abrasion is likely to promote caries and acid erosion.

At and below 45 ppm [F^–] in the solution, F MAS-NMR showed fluoride-substituted apatite formation, and above 45 ppm, calcium fluoride (CaF₂) formed in increasing proportions. Further increases in [F^–] caused no further reduction in demineralization, but increased the proportion of CaF₂ formed.

Remineralization of subsurface enamel lesions requires a considerable amount of exposure time. Orthodontists also are aware that rinses and gels containing high fluoride concentrations do not allow white-spot lesions adjacent to brackets to revert back to the normal translucent luster of sound enamel